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Synthesis and cytotoxicity of some acetylated alkaloids of Hymenocallis littoralis

Dinh Thi Phuong Anh, Tran Bach Duong, Vu Dinh Hoang

Abstract


11-O-acetyltazettine (2), 2-O-acetyllycorine (4), 1,2-O,O’-diacetyllycorine (5), and 11-O-acetylhaemanthamine (7) were synthesized  from tazettine (1), lycorine (3) and haemanthamine (6) isolated from the whole plant of Hymenocallis littoralis. Structures of the compounds were elucidated by means of spectroscopic methods. All the alkaloids and their derivatives were tested for cytotoxicity activities to KB and Hep G2 cell lines.

Keywords: Hymenocallis littoralis, alkaloid, acetylated derivatives, cytotoxicity activity.

Keywords


Hymenocallis littoralis, alkaloid, acetylated derivatives, cytotoxicity activity.