Khảo sát phản ứng C-axetyl hóa một số aryl metyl ete trong điều kiện hóa học xanh

Abstract

Alkyl aryl ketone is an important intermediate in the synthesis of biologically active molecules. It is usually synthesized by Friedel-Crafts acylation of aromatic compound in the presence of excess Lewis acid, AlCl3. In this study, copper triflate Cu(OTf)2was used as a new generation Lewis acid catalyst in Friedel-Crafts acylation. The reaction was taken place under microwave irradiation on anisole and veratrole. Copper triflate is safe-to-handle, recoverable and reusable.