ĐIỀU CHẾ VÀ TÍNH CHẤT CỦA 5-(4-AXETAMIDO-2-CLOARYL)-1,3,4-OXADIAZOL-2-THIOL

Nguyễn Thị Sơn, Hà Minh Tú, Lưu Văn Bôi
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Authors

  • Nguyễn Thị Sơn
  • Hà Minh Tú
  • Lưu Văn Bôi

DOI:

https://doi.org/10.15625/2061

Abstract

Thiocarbamoylation 4-acetamido-2-chlorobenzoyl hydrazide by tetramethylthiuram disulphide (TMTD) afforded 5-(4-acetamido-2-chlorophenyl)-1,3,4-oxadiazole. Reaction of the later with  N-a-cloacetanilide derivatives run into two alternative ways. In the alkaline solution 2-arylamino-5-(acetamido-2-chlorophenyl)-1,3,4-oxadiazole has been isolated, but in the neutral medium 2-(N-carboxamidoarylmethylthio)-5-(4-acetamido-2-chlorophenyl)-1,3,4-oxadiazole have been obtained as the main product.  The structures of the products have been confirmed by the spectroscopic data and the biological activities have been tested.

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Published

14-08-2012

How to Cite

Sơn, N. T., Tú, H. M., & Bôi, L. V. (2012). ĐIỀU CHẾ VÀ TÍNH CHẤT CỦA 5-(4-AXETAMIDO-2-CLOARYL)-1,3,4-OXADIAZOL-2-THIOL. Vietnam Journal of Chemistry, 49(1). https://doi.org/10.15625/2061

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