Tổng hợp chọn lọc lập thể tubuphenylalanine axit (Tup) của tubulysin

Lê Văn Hải, Trần Tuấn Anh, Trần Văn Lộc, Trần Văn Chiến
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Authors

  • Lê Văn Hải
  • Trần Tuấn Anh
  • Trần Văn Lộc
  • Trần Văn Chiến

DOI:

https://doi.org/10.15625/2525-2321.2017-00477

Keywords:

Wittig reaction, triethyl-2-phosphonopropionate, phenylalanine

Abstract

A highly stereoselective synthesis of tubuphenylalanine fragment (9) of tubulysin is described with the key step of Wittig condensation reaction and stereoselective hydrogenation of double bond. The desired product was confirmed by 1D and 2D-NMR spectroscopies.

Keywords. Wittig reaction, triethyl-2-phosphonopropionate, phenylalanine.

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References

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Published

30-06-2017

How to Cite

Hải, L. V., Anh, T. T., Lộc, T. V., & Chiến, T. V. (2017). Tổng hợp chọn lọc lập thể tubuphenylalanine axit (Tup) của tubulysin. Vietnam Journal of Chemistry, 55(3), 384. https://doi.org/10.15625/2525-2321.2017-00477

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