Tổng hợp một số 2-amino-6-aryl-4-(4’-hydroxy-n-metylquinolin-2’-on-3’-yl)pyrimidin

Dương Ngọc Toàn, Trần Phương Anh, Nguyễn Minh Thảo
Author affiliations

Authors

  • Dương Ngọc Toàn
  • Trần Phương Anh
  • Nguyễn Minh Thảo

DOI:

https://doi.org/10.15625/2525-2321.2017-00460

Keywords:

Pyrimidines, methylquinolin, guanidine chlorohydrate, a, b-unsaturated ketones.

Abstract

Six new 2-amino-6-aryl-4-(4’-hydroxy-N-methylquinolin-2’-on-3’-yl)pyrimidines have been synthesized from a,b-unsaturated ketones of 3-acetyl-4-hydroxy-N-methylquinolin-2-on by reaction of corresponding a,b-unsaturated ketones with guanidine chlorohydrate. The purity and structure of the obtained products have been confirmed by thin layer chromatography, IR, 1H NMR, 13C NMR, HSQC, HMBC and MS spectra.

Keywords. Pyrimidines, methylquinolin, guanidine chlorohydrate, a,b-unsaturated ketones.

Downloads

Download data is not yet available.

References

K. L. Sayle, J. Bentley, F. T. Boyle, A. H. Calvert, Y. Cheng, N. J. Curtin, J. A. Endicott, B. T. Golding, I. R. Hardcastle, P. Jewsbury, V. Mesguiche, D. R. Newell, M. E. M. Noble, R. J. Parsons, D. J. Pratt, L. Z. Wang and R. J. Griffin. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2., Bioorg. Med. Chem. Lett., 13, 3079 (2003).

Gadhachanda V.R., Wu B., Wang Z., Kuhen K.L., Caldwell J., Zondler H., Walter H., Havenhand M., He Y. 4-Amino-pyrimidines as novel HIV-1 inhibitors, Bioorg. Med. Chem. Lett., 17, 260-265 (2007).

Xie F, Zhao HB, Zhao L, Luo L, Hu Y. Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity, Bioorg. Med. Chem. Lett., 19, 275-278 (2009).

A. Agarwal, K. Srivastava, S.K. Puri and P. M. S. Chauhan. Antimalarial activity of 2,4,6-trisubstituted pyrimidines, Bioorg. Med. Chem. Lett., 15(7), 1881-1883 (2005).

Dương Ngọc Toàn. Luận án Tiến sĩ Hóa học, Trường Đại học Khoa học Tự nhiên – Đại học Quốc gia Hà Nội, Hà Nội (2015).

Nguyễn Minh Thảo, Vũ Thị Minh Thư, Trần Văn Sơn. Tạp chí Hoá học, 48(2), 157 (2010).

Elliott R., Snell B. K., Pyrimidin derivatives, US Pat, 4, 902, 332 (1990).

Jain K. S., Chitre T. S., Miniyar P. B., Kathiravan M. K., Bendre V. S., Veer V. S., Shahane S. R. and Shishoo C. J. Biological and medicinal significance of pyrimidines, Current Science, 90(6) (2006).

Downloads

Published

30-06-2017

How to Cite

Toàn, D. N., Anh, T. P., & Thảo, N. M. (2017). Tổng hợp một số 2-amino-6-aryl-4-(4’-hydroxy-n-metylquinolin-2’-on-3’-yl)pyrimidin. Vietnam Journal of Chemistry, 55(3), 290. https://doi.org/10.15625/2525-2321.2017-00460

Issue

Section

Articles