Tổng hợp, cấu trúc, hoạt tính kháng tế bào ung thư của hai phức chất platin(II) chứa metyleugenol và p-cloanilin

Abstract

Two organometallic complexes of platinum(II), [PtCl₂(Meug)(p-ClC₆H₄NH₂)] (M1) and [PtCl(Meug-1H)(p-ClC₆H₄NH₂)] (M2) (Meug: methyleugenol), have been synthesized for the first time. The structures of  M1 and M2 were determined by crystalline water, Pt analysis, EDX, IR, ¹H NMR, ¹³C NMR and HSQC spectra studies. In these complexes, p-chloroaniline coordinates with the Pt(II) via N. In M1, Meug only coordinates with Pt(II) through C=C of the allyl group and the N atom occupies the trans-position in comparison to the allyl group. In M2, deprotonated Meug (Meug-1H) is bound up with platinum(II) both at ethylenic double bond of allyl group and at the C5 atom of benzene ring resulting in the cyclic complexe in which the N atom and the allyl group are cis positions to each other. M2 exhibits activity against MCF7 human cancer cell line with IC₅₀ value of 92.23 μg/ml.