Tổng hợp kháng sinh cefuroxim từ 7-ACA

Nguyễn Khánh Tân, Đoàn Ngọc Nhuận
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Authors

  • Nguyễn Khánh Tân
  • Đoàn Ngọc Nhuận

DOI:

https://doi.org/10.15625/0866-7144.2016-00326

Keywords:

7-ACA, SMIA, decarbamoyl cefuroxime acid, cefuroxime

Abstract

Cefuroxime -a second generation cephalosporin antibiotic- is synthesized from starting materials 7-ACA (7-aminocephalosporinic acid) and SMIA (2-furanyl-(Z)-2-methoxyiminoacetic acid ammonium salt). The study showed that the product could be prepared via 4 steps scheme to obtain cefuroxime in good total yield (42 % yield). The novel of the process, that we use oxalyl chloride replaces phosphoryl chloride in step 2: help reaction of step 2 gain yield better.

Keywords. 7-ACA, SMIA, decarbamoyl cefuroxime acid, cefuroxime.

 

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Published

19-07-2016

How to Cite

Tân, N. K., & Nhuận, Đoàn N. (2016). Tổng hợp kháng sinh cefuroxim từ 7-ACA. Vietnam Journal of Chemistry, 54(3), 396. https://doi.org/10.15625/0866-7144.2016-00326

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Articles