Sơ bộ đánh giá dư lượng một số thuốc giảm đau không thuộc nhóm steroid trong nước thải Hà Nội

Abstract

In this report, the simultaneous determination procedure of four nonsteroidal anti-inflammatory drugs (NSAIDs): ibuprofen, bezafibrate, naproxen, diclofenac in wastewater was applied to 20 wastewater samples collected in Hanoi. The procedure for analysis of these NSAIDs is including two steps: first extraction/trace enrichment by solid phase extraction method and then followed by quantitative determination by portable automated capillary electrophoresis (CE) equipment with capacitively coupled contactless conductivity detector (C⁴D). The obtained analysis result showed the presence of ibuprofen in 12 samples with concentrations ranging from 6.98-38.7 μg/L and bezafibrate in only 1 sample with concentration of 45.3 μg/L. The CE-C⁴D method was cross-checked by the high-performance liquid chromatography method (HPLC) with DAD detector, the deviation of the result obtained by CE-C4D compared to those with the standard reference method (HPLC-DAD) was less than 20 %.

Keywords. Capillary electrophoresis, anti-inflammatory drugs, Hanoi wastewater.