Evaluation of biological activities of polysaccharides and compounds isolated from Lentinus edodes

Tran Thi Hong Ha; Luu Van Chinh; Le Huu Cuong; Tran Thi Nhu Hang; Do Huu Nghi; Truong Ngoc Hung; Nguyen Thi Nga; Le Mai Huong

doi:10.15625/0866-7160/v35n4.3773

Evaluation of biological activities of polysaccharides and compounds isolated from Lentinus edodes

Tran Thi Hong Ha, Luu Van Chinh, Le Huu Cuong, Tran Thi Nhu Hang, Do Huu Nghi, Truong Ngoc Hung, Nguyen Thi Nga, Le Mai Huong

Author affiliations

Authors

Tran Thi Hong Ha VAST
Luu Van Chinh VAST
Le Huu Cuong
Tran Thi Nhu Hang
Do Huu Nghi
Truong Ngoc Hung
Nguyen Thi Nga
Le Mai Huong VAST

DOI:

https://doi.org/10.15625/0866-7160/v35n4.3773

Keywords:

Lentinus edodes, Antioxidant, Cytotoxicity, Polysaccharides.

Abstract

Two polysaccharide samples (Poly1 and Poly2) and three compounds (galactiol, ergosterol and ergosterol peroxide) were isolated from the fruiting body of Lentinus edodes. Poly1 and ergosterol peroxide (NH-3) showed cytotoxicities against two liver cancer cell lines Hep-G2 (Hepatocellular carcinoma) and RD (Rhabdomyosarcoma) with IC₅₀ values of 29.62 and 34.24; 3.84 and 7.61 mg/mL respectively. Poly1 and NH-3 showed capacities for decreasing Hep-G2 tumor density by 54.09 and 58.33%, respectiviely in comparison to the control. In addtion, the average sizes of tumors treated with Poly1 and NH-3 were decreased by 35.36 and 55.18%, respectively as compared to the control.

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Published

19-12-2013

How to Cite

Hong Ha, T. T., Chinh, L. V., Cuong, L. H., Nhu Hang, T. T., Nghi, D. H., Hung, T. N., Nga, N. T., & Huong, L. M. (2013). Evaluation of biological activities of polysaccharides and compounds isolated from Lentinus edodes. Academia Journal of Biology, 35(4), 445–453. https://doi.org/10.15625/0866-7160/v35n4.3773