INFLUENCE OF POLYETHYLENE OXIDE CONTENT ON SOME CHARACTERISTICS OF PLA/CS FILMS LOADING NIFEDIPINE

Nguyen Thuy Chinh, Trang Thi Thu Nguyen, Mai Thi Tran, Cong Van Do, Huynh Duc Mai, Trung Huu Tran, Thang Viet Vu, Hoang Thai, Giang Vu Nguyen

Abstract


This work mentions the effect of polyethylene oxide (PEO) content on some characteristics and properties of polylactic acid (PLA)/chitosan (CS) films loading nifedipine (NIF). The water contact angle, droplet size values and Field Emission Scanning Electron Microscopy (FESEM) images  of the films are used to investigate their morphology and hydrophobicity. The obtained results show that the hydrophobic property of the PLA/CS/NIF films is improved by the presence of PEO. Besides, the PLA/CS/NIF films containing PEO have tighter structure and water absorbed ability less than those of the PLA/CS/NIF films

Keywords


Polyethylene oxide, compatibility, nifedipine, PLA/CS, morphology, hydrolysis

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DOI: https://doi.org/10.15625/2525-2518/55/6/9617

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Published by Vietnam Academy of Science and Technology