HEPATOPROTECTIVE EFFECTS OF PHENOLIC GLYCOSIDES FROM THE METHANOL EXTRACT OF PHYSALIS ANGULATA

Hoang Le Tuan Anh, Duong Thi Dung, Dong Thanh Tuan, Trieu Quy Hung, Pham Thi Hai Yen, Tran Hong Quang, Nguyen Xuan Nhiem, Chau Van Minh, Duong Thi Hai Yen, Phan Van Kiem

Abstract


By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-O-triglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and in comparison with the reported data. Compounds 3 exhibited significantly hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata.

Keywords


Physalis angulata, phenolic glycoside, hepatoprotective effect

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Published by Vietnam Academy of Science and Technology