Green organic synthesis of N-methylpyrrolidine

Nguyen Van Hoa, Nguyen Anh Tuan, Phan Thanh Thao, Trinh Thi Thanh Huyen
Author affiliations

Authors

  • Nguyen Van Hoa Institute of Chemical Technology, VAST, 1 Mac Đinh Chi Street, District 1, Ho Chi Minh City, Viet Nam
  • Nguyen Anh Tuan Institute of Chemical Technology, VAST, 1 Mac Đinh Chi Street, District 1, Ho Chi Minh City, Viet Nam
  • Phan Thanh Thao Institute of Chemical Technology, VAST, 1 Mac Đinh Chi Street, District 1, Ho Chi Minh City, Viet Nam
  • Trinh Thi Thanh Huyen Institute of Chemical Technology, VAST, 1 Mac Đinh Chi Street, District 1, Ho Chi Minh City, Viet Nam

DOI:

https://doi.org/10.15625/0866-708X/54/2/6772

Keywords:

Tertiary amines, alkylation, aqueous media

Abstract

N-methylpyrrolidine was successfully synthesized in an aqueous medium by using methylamine and 1,4-dibromobutane in the presence of catalyst K2CO3 at a moderated temperature. Here, N-methylpyrrolidine was firstly synthesized via the green chemistry process, in which both the water solvent and potassium carbonatecatalyst were inexpensive and environmentally friendly. Also, the reaction temperature was quite moderated at 900C. As a result, the current synthesis process was highly potential to implement in practice. Since the product yield directly depended on the operating conditions, the catalysts, temperature, ratio of reactants and solvent would be critical factors. In the present study, the structure of N-methylpyrrolidine product was confirmed by using the IR, 1H-NMR, 13C-NMR and Gas Chromatography-Mass spectroscopy (GC-MS).

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Published

12-04-2016

How to Cite

[1]
N. V. Hoa, N. A. Tuan, P. T. Thao, and T. T. T. Huyen, “Green organic synthesis of N-methylpyrrolidine”, Vietnam J. Sci. Technol., vol. 54, no. 2, pp. 231–237, Apr. 2016.

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Articles