BIOACTIVE SAPONINS FROM PANAX BIPINNATIFIDUS SEEM. GROWING IN VIETNAM

Hoang Anh Thi Nguyen, Tung Huu Nguyen, Hieu Trung Pham, Duong Quang Pham, Quang Le Dang, Hoang Dinh Vu

Abstract


Panax bipinnatifidus Seem. belonging to the family Araliaceae has been used as a folk medicine in Viet Nam. Our ongoing study on bioactive compounds from Panax bipinnatifidus Seem. collected in Sapa, Lao Cai resulted in the isolation of two saponins together with the well-known saponin Stipuleanoside R2. Their structures were identified as 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucuronopyranosyloleanolic acid (1) and Stipuleanoside R1 (2) based on NMR spectroscopic data as well as comparison with the literature data. For the first time, 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucuronopyranosyloleanolic acid (1) was found in genus Panax. On biological screening, the crude extract and the principal saponin, stipuleanoside R2 showed weak inhibitory effect on markedly nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells.

Keywords


Panax bipinnatifidus Seem.; 3-O-β-d-glucopyranosyl-(1→3)-β-d-glucuronopyranosyloleanolic acid; Stipuleanoside R1

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References


Tap N. - Panax L. species growing in Vietnam, Vietnam J. Med. Mater. 10 (2005) 71-76.

Bich D. H. - Medicinal plants and animals in Vietnam, Science and Technology publisher, Vietnam, 2004, (in Vietnamese).

Yang W-Z., Hu. Y., Wu. W-Y., Ye. M., and Guo. D-A. - Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity, Phytochemistry 106 (2014) 7- 24. https://doi.org/ 10.1016/j.phytochem.2014.07.012.

Nguyen H. T., Nguyen T. H. A., Chu V. T., Pham T. H, Pham Q. D., Le Dang Q., and Vu D. H. - Oleanane-type saponins from the aerial parts of Panax bipinnatifidus, Nat. Prod. Commun. 15 (2020) 1-5. https://doi.org/10.1177/1934578X20926278.

Nguyen H. T., Tran H. Q., Nguyen T. T. N., Chau V. M., Bui K. A., Pham Q. L., Nguyen M. C., and Kim Y. H. - Oleanolic triterpene saponins from the roots of Panax bipinnatifidus, Chem. Pharm. Bull. 59 (2011) 1417-1420. https://doi.org/10.1248/cpb.59.1417.

Vu T. T., Nguyen H. T., Dang V. D., Dang T. T., Nguyen T. H., Dinh D. L., Bui T. T., Pham T. H., and Duong T. L. H. - Antithrombotic activity and saponin composition of the roots of Panax bipinnatifidus Seem. Growing in Vietnam, Pharmacogn. Res. 10 (4) (2018) 333-338. https://doi.org/10.4103/pr.pr_58_18.

Do V. H., Nguyen T. H., Nguyen T. T. T., and Dang T. N. - Study on chemical constituents from the roots of Panax bipinnatifidus Seem. Collected in Sapa, Laocai, VNU J. Sci.: Med. Pharm. Sci. 33 (2) (2017) 50-55. https://doi.org/10.25073/2588-1132/vnumps.4079.

Sakai S., Katsumata M., Satoh Y., Nagasao M., Miyakoshi M., Ida Y., and Shoji J. - Oleanolic acid saponins from root bark of Aralia elata, Phytochemistry 35 (1994) 1319-1324. https://doi.org/10.1016/S0031-9422(00)94846-5.

Liang. C., Ding Y., Nguyen H. T., Kim J-A., Boo H-J., Kang H-K., Nguyen M. C., and Kim Y. H. - Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities, Bioorg. Med. Chem. Lett. 20 (2010) 7110-7115. https://doi.org/10.1016/j.bmcl.2010.09.074

Agrawal P. K. - NMR spectroscopy in the structural elucidation of oligosaccharides and glycosides, Phytochemistry 31 (1992) 3307-3330. https://doi.org/10.1016/0031-9422(92)83678-r.

Nguyen T. T. A, Nguyen T. T. A., Nguyen T. T. H., Nguyen S. N., and Nguyen P. K. P. - Oleanane saponins from Polyscias Guilfoylei Bail. (Araliaceae), Sci. Tech. Dev. J. 12 (2009) 21-28.

Green L. C., Wagner D. A., Glogowski J., Skipper P. L., Wishnok J. S., and Tannenbaum S. R. - Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem. 126 (1) (1982), 131-138. https://doi.org/10.1016/0003-2697(82)90118-X.




DOI: https://doi.org/10.15625/2525-2518/58/6A/15537 Display counter: Abstract : 30 views. PDF : 8 views.

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