An Kim Nguyen Thi, Ngo Dai Quang, Pham Quoc Long, Tran Thi Thu Thuy


From our ongoing study on the latex of Garcinia cowa Roxb. ex Choisy collected in Quy Chau, Nghe An province, seven compounds were isolated including four prenylated xanthones: norcowanin (1), kaennacowanol A (2), garcinone D (3), fuscaxanthone I (4); one tocotrienol: parvifoliol F (5) and two triterpenes: stigmasterol (6), lupeol (7). The structures of the isolated compounds were elucidated by physico-chemical spectroscopic analysis and by comparison with reported data. To the best of our knowledge, garcinone D (3), fuscaxanthone I (4) and parvifoliol F (5) were first reported as components of Garcinia cowa


Garcinia cowa, norcowanin, kaennacowanol A, garcinone D, fuscaxanthone I.

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na Pattalung P., Thongtheeraparp W., Wiriyachitra P. and Taylor W.C. - Xanthones of Garcinia cowa, Planta Med 60 (4) (1994) 365-368. https://doi.org/10.1055/s-2006-959502.

Pham, H.H. - Vietnamese plants, Youth Publishing House, 1999.

Ritthiwigrom T., Laphookhieo S. and Pyne S. - Chemical constituents and biological activities of Garcinia cowa Roxb, Maejo Int. J. Sci. Technol. 7 (2013) 212-231. https://core.ac.uk/download/pdf/26821264.pdf.

Fatma Sri W., Daud Ahmad Israf A., Nordin Hj L., Dachriyanus, Salau B.A. and Ashok Kumar J. - Anti-inflammatory activity of isolated compounds from the stem bark of Garcinia cowa Roxb, Pharmacognosy Journal 9 (1) (2017) 55-57. https://doi.org/10.5530/PJ.2017.1.10.

Panthong, K., Hutadilok-Towatana N. and Panthong A. - Cowaxanthone F, a new tetraoxygenated xanthone, and other anti-inflammatory and antioxidant compounds from Garcinia cowa, Canadian Journal of Chemistry 87 (2009) 1636-1640. https://doi.org/10.1139/V09-123.

Likhitwitayawuid K., Phadungcharoen T. and Krungkrai J. - Antimalarial xanthones from Garcinia cowa, Planta Med 64 (1) (1998) 70-72. https://doi.org/10.1055/s-2006-957370.

Auranwiwat C., Trisuwan K., Saiai A., Pyne S.G. and Ritthiwigrom T. - Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa, Fitoterapia 98 (2014) 179-183. https://doi.org/10.1016/j.fitote.2014.08.003.

Siridechakorn I., Phakhodee W., Ritthiwigrom T., Promgool T., Deachathai S., Cheenpracha S., Prawat U. and Laphookhieo S. - Antibacterial dihydrobenzopyran and xanthone derivatives from Garcinia cowa stem barks, Fitoterapia 83 (8) (2012) 1430-1434. https://doi.org/10.1016/j.fitote.2012.08.006.

Laphookhieo S., Cheenpracha S., Phakhodee W., Ritthiwigrom T. and Prawat U. - A new depsidone from the twigs of Garcinia cowa, Heterocycles 83 (2011) 1139. https://doi.org/10.3987/COM-11-12163.

Tian Z., Shen J., Moseman A.P., Yang Q., Yang J., Xiao P., Wu E. and Kohane I.S. - Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells, Int J Cancer 122 (1) (2008) 31-38. https://doi.org/10.1002/ijc.23048.

Xu G., Kan W.L.T., Zhou Y., Song J.-Z., Han Q.-B., Qiao C.-F., Cho C.-H., Rudd J.A., Lin G. and Xu H.-X. - Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa, Journal of Natural Products 73 (2) (2010) 104-108. https://doi.org/10.1021/np9004147.

Kaennakam S., Siripong P. and Tip-Pyang S. - Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa, Fitoterapia 102 (2015) 171-176. https://doi.org/10.1016/j.fitote.2015.03.008.

Xu Z., Huang L., Chen X.H., Zhu X.F., Qian X.J., Feng G.K., Lan W.J. and Li H.J. - Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana, Molecules 19 (2) (2014) 1820-1827. https://doi.org/10.3390/molecules19021820.

Nguyen T.K.A., Dinh T.H., Pham Q.L. and Tran T.T.T. - Tetraoxygenated xanthones from the latex of Garcinia cowa growing in Viet Nam, Vietnam Journal of Science and Technology 56 (5) (2018) 560-566. https://doi.org/10.15625/2525-2518/56/5/11826

Saeed N., Khan M.R. and Shabbir M. - Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L, BMC Complement Altern Med 12 (2012) 221. https://doi.org/10.1186/1472-6882-12-221.

Ragasa C., Tabin T.J., Reyes J.M.A., Carmen M. and Shen C.C. - Xanthones from Garcinia mangostana Linn. Pulp., Der Pharmacia Lettre 8 (20) (2016) 188-190. https://doi.org/10.1016/S0040-4020(01)98253-5.

Nguyen, T.H. - Phytochemical and biological investigation of the bark of Garcinia fusca Pierre, Doctoral thesis in Faculty of Chemistry and Pharmacy, University of Regensburg, 2015. https://epub.uni-regensburg.de/32015/1/Dissertation-final-library.PDF.

Rukachaisirikul V., Naklue W., Phongpaichit S., Towatana N.H. and Maneenoon K. - Phloroglucinols, depsidones and xanthones from the twigs of Garcinia parvifolia, Tetrahedron 62 (36) (2006) 8578-8585. https://doi.org/10.1016/j.tet.2006.06.059.

Chaturvedula V.S.P. and Prakash I. - Isolation of stigmasterol and β-sitosterol from the dichloromethane extract of Rubus suavissimus, Chaturvedula and Prakash, International Current Pharmaceutical Journal 1 (9) (2012) 239-242. https://doi.org/10.3329/icpj.v1i9.11613.

Laghari A.H., Memon S., Nelofar A. and Khan K.M. - Alhagi maurorum: A convenient source of lupeol, Industrial Crops and Products 34 (2011) 1141–1145. https://doi.org/10.1016/j.indcrop.2011.03.031.

DOI: https://doi.org/10.15625/2525-2518/58/6A/15531 Display counter: Abstract : 15 views. PDF : 12 views.


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