SCREENING AND PRILIMINARY STUDY ON MICROBIAL STRAINS WITH INHIBITORY ACTIVITY AGAINST ENZYMES RELATING TO DIABETES IN VIETNAM

Chi Kim Hoang, Ha Thi Hong Tran, Cuong Huu Le, Quang Ho Tran, Huong Mai Le, Hang Thi Nhu Tran

Abstract


ABSTRACT – HCTN7

Microorganisms are considered a rich and potential source for the bioactive guided exploitation of natural products. Commonly used enzyme inhibitors for diabetes treatment hitherto such as α-amylase and α-glucosidase inhibitors are mostly microbial sources derived. The present study was carried out with the aim of screening and questing microbial inhibitors against the most popular diabetes-related enzymes (α-amylase, α-glucosidase and PTP1B) in Vietnam. The investigation results revealed 19 of all 100 tested microbial crude extracts exhibiting inhibitory activity against at least one enzyme. Basing on morphological, physiological, biochemical, and rRNA 16/18S gene sequencing, the phylogeny of the most potent microbial strains was indentfied. The research results contributed confirming the potential of the research for natural compounds from microorganisms, and supported new materials for further studies to exploit medicinal active ingredients from microbial sources.


Keywords


α-amylase inhibitor, α-glucosidase inhibitor, PTP1B inhibitor, microorganisms, Bacillus, Streptomyces, Talaromyces, Enterobacter.

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References


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DOI: https://doi.org/10.15625/2525-2518/58/6A/15528 Display counter: Abstract : 23 views. PDF : 5 views.

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