STRUCTURE AND BIOLOGICAL ACTIVITY OF FIVE FLAVO-NOIDS FROM AMPELOPSIS CANTONIENSIS

Thuy Thi Thu Thanh, Thu Thi Xuan Nguyen, Quang Van Ngo, Long Duc Dang

Abstract


In this paper, phytochemical studied on ethanol extract of Ampelopsi cantoniensis led to obtain five flavonoid compounds: myricitrin, myricetin, quercetin, dihydromyricetin, and phloretin. Their structure was confirmed by NMR and ESI-MS methods. Antioxidant and anti-diabetic activities of the compounds were evaluated. The results showed that all five flavonoids have strong DPPH radical scavenging activity with SC50 values ranging from 9.42–35.37 μM. Four of them (myricetin, phloretin, myricitrin and quercetin) are strong α-glucosidase and α-amylase inhibitors with IC50 values ranging from 8.92–18.74 µM for α-glucosidase inhibition and from 9.64 – 136.58 µM for α-amylase inhibition.


Keywords


Ampelopsi cantoniensis, flavonoid, antioxidant activity, α-glucosidase and α-amylase inhibitor .

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References


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DOI: https://doi.org/10.15625/2525-2518/58/6A/15513 Display counter: Abstract : 17 views. PDF : 7 views.

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