MICROWAVE-ASSISTED THE CLAISEN-SCHMIDT CONDENSATION BETWEEN ARYLMETHYL KETONES AND ARYL ALDEHYDES CATALYZED BY CU(OTF)2 UNDER SOLVENT-FREE CONDITIONS. SYNTHESIS OF CHALCONES

Dau Xuan Duc, Nguyen Thi Chung

Abstract


An environmentally friendly and high yield method for the Claisen-Schmidt condensation has been investigated. A Mixture of an arylmethyl ketone and an aldehyde was irradiated in a microwave reactor for 20 minute using Cu(OTf)2 as catalyst in solvent-free conditions. 12 chalcones were synthesized in moderate to excellent yields (67-91%). This is the first time the Claisen-Schmidt condensation with Cu(OTf)2 under microwave irradiation was reported.

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DOI: https://doi.org/10.15625/2525-2518/58/6A/15407 Display counter: Abstract : 35 views. PDF : 20 views.

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