Alkaloids and cyclopeptides from the marine-derived fungus Aspergillus sp. M512

Do Thi Quynh, Cao Duc Tuan, Dang Van Chuc, Hoang Thi Hong Lien, Le Khanh Huyen, Le Thi Hong Minh, Pham Van Cuong, Nguyen Van Hung, Young Ho Kim, Doan Thi Mai Huong
Author affiliations

Authors

  • Do Thi Quynh Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Cao Duc Tuan Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Dang Van Chuc Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Hoang Thi Hong Lien Department of Science and Technology, Haiphong University, Hai Phong, Viet Nam
  • Le Khanh Huyen Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Le Thi Hong Minh Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Van Cuong Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Van Hung Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Young Ho Kim College of Pharmacy, Chungnam National University, Korea
  • Doan Thi Mai Huong Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/5/15022

Keywords:

Aspergillus, alkaloid, cyclodipeptide, antimicrobial activity

Abstract

In the course of our screening program, the EtOAc extract of an Aspergillus sp. (strain M512) exhibited antimicrobial activities against three Gram Positive bacteria, and one yeast strain. This paper reported the isolation and structural elucidation of seven secondary metabolites including two alkaloids (1-2) and five cyclodipeptides (3-7) from culture broth of Aspergillus sp. M517. All isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Except compound 1 and 2, with MIC values ranged from 32 to 128 μg/mL, five other compounds do not show inhibition activities against tested microorganisms.

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References

Imhoff J. F. - Natural products from marine fungi - Still an underrepresented resource. Mar. Drugs. 14, (2016) 19.

Hasan S., Ansari M. I., Ahmad A., Mishra M. -Major bioactive metabolites from marine fungi: Areview. Biomedical Informatics 11(4) (2015) 176-181.

Bugni, T.S.; Ireland, C.M. - Marine-derived fungi: A chemically and biologically diverse group of microorganisms. Nat. Prod. Rep. 21 (2004) 143–163.

Tran H. Q., Dong C. K., Phan V. K., Chau V. M., Nguyen X. N., Bui H. T., Pham H. Y., Nguyen T. T. N.n, Hye Jin Kim, Hyuncheol O.- Macrolide and phenolic metabolites from the marine-derived fungus Paraconiothyrium sp. VK-13 with anti-inflammatory activity, The Journal of Antibiotics 71(9) (2018) 826-830.

Le T. H. M., Do T. Q., Doan T. M. H., Vu T. Q., Nguyen M. A., Vu T. T. H., Nguyen H. D., Nguyen T. T. D., Tran M. H., Chau V. M. and Pham V. C. - Chemical composition and biological activities of metabolites from the marine fungi Penicillium sp. isolated from sediments of Co To Island, Vietnam. Molecules 24 (2019) 3830

Vu T. Q., Tran V. H., Doan T. M. H., Le C. V., Le H. M., Brian T. M., Chau V. M. and Pham V. C. - Antimicrobial Metabolites from a Marine-Derived Actinomycete in Vietnam’s East Sea, Natural Product communication 11(1) (2015) 49- 51

Zheng L., Yan X., Han X., Chen H., Lin W., Lee F.S., Wang X. - Identification of norharman as the cytotoxic compound produced by the sponge (Hymeniacidon perleve)-associated marine bacterium Pseudoalteromonas piscicida and its apoptotic effect on cancer cells, Biotechnol Appl Biochem. 44 (2006) 135-142.

Katrin S., Jorgen S., Anders B., and Johan S. - Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe–L-Pro) and Cyclo(L-Phe–trans-4-OH-L-Pro) and 3-Phenyllactic Acid, Applied and Environmental Microbiology 68 (2002) 4322–4327.

Fdhila F., Vazquez V., Sanchez J. L., Riguera R. - DD-Diketopiperazines. Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus. J. Nat. Prod. 66(10) (2003) 1299-1301.

Wang G., Dai S., Chen M., Wu H., Xie L., Luo X., Li X. - Two diketopiperazine cyclo(Pro-Phe) isomers from marine bacterium Bacillus subtilis sp. 13-2, Chem. Nat. Compd. 46(4) (2010) 583-585.

Chapla V. M., Zeraik M. L., Leptokarydis I. H., Silva G. H., Bolzani V. S., Young M. C. M. - Antifungal compounds produced by Colletotrichum gloeosporioides, an endophytic fungus from Michelia champaca, Molecules 19(11) (2014) 19243-19252.

Ying Y., Zhan Z., Ding Z., San W. G.- Bioactive metabolites from Penicillium sp. P-1, a fungal endophyte in Huperzia serrate, Chem. Nat. Compd. 47 (2011) 541-544.

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Published

16-10-2020

How to Cite

[1]
D. T. . Quynh, “Alkaloids and cyclopeptides from the marine-derived fungus Aspergillus sp. M512”, Vietnam J. Sci. Technol., vol. 58, no. 5, pp. 541–548, Oct. 2020.

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Section

Natural Products

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