Lignans from leaves of Amesiodendron chinense and their cytotoxic activity

Ho Van Ban, Trinh Thi Thanh Van, Vu Van Chien, Nguyen Thi Hue, Pham Thi Hang, Nguyen Le Tuan, Nguyen Xuan Nhiem, Pham Van Cuong, Nguyen Quoc Vuong
Author affiliations

Authors

  • Ho Van Ban Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Trinh Thi Thanh Van Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Vu Van Chien Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Thi Hue Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Thi Hang Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Le Tuan Natural Science department, Quy Nhon University, 170 An Duong Vuong, Quy Nhon, Viet Nam
  • Nguyen Xuan Nhiem Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Van Cuong Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Quoc Vuong Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/4/14877

Keywords:

Amesiodendron chinense, ( )-aptosimon, ( )-isolariciresinol, cleomiscosin A, cleomiscosin C, cytotoxicity.

Abstract

ABSTRACT

From leaves of Amesiodendron chinense (Mer.) Hu four lignans (+)-aptosimon (1), (+)-isolariciresinol (2), (-)-cleomiscosin A (3), and (-)-cleomiscosin C (3) were isolated. Their structures were determined by spectroscopic analysis including MS, 1D and 2D NMR as well as by comparison with reported data in literature. All compounds were evaluated for cytotoxic activities against five human cancer cell lines, KB, SK-LU-1, MCF-7, HepG-2, and SW-480. They showed weak cytotoxic activity on five tested human cancer cell lines with IC50 values ranging from 32.61 to 95.18 µg/ml.

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References

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Published

13-07-2020

How to Cite

[1]
H. V. Ban, “Lignans from leaves of Amesiodendron chinense and their cytotoxic activity”, Vietnam J. Sci. Technol., vol. 58, no. 4, pp. 442–449, Jul. 2020.

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Section

Natural Products

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