LIGNANS FROM LEAVES OF AMESIODENDRON CHINENSE AND THEIR CYTOTOXIC ACTIVITY

Ho Van Ban, Trinh Thi Thanh Van, Vu Van Chien, Nguyen Thi Hue, Pham Thi Hang, Nguyen Le Tuan, Nguyen Xuan Nhiem, Pham Van Cuong, Nguyen Quoc Vuong

Abstract


ABSTRACT

From leaves of Amesiodendron chinense (Mer.) Hu four lignans (+)-aptosimon (1), (+)-isolariciresinol (2), (-)-cleomiscosin A (3), and (-)-cleomiscosin C (3) were isolated. Their structures were determined by spectroscopic analysis including MS, 1D and 2D NMR as well as by comparison with reported data in literature. All compounds were evaluated for cytotoxic activities against five human cancer cell lines, KB, SK-LU-1, MCF-7, HepG-2, and SW-480. They showed weak cytotoxic activity on five tested human cancer cell lines with IC50 values ranging from 32.61 to 95.18 µg/ml.


Keywords


Amesiodendron chinense, (+)-aptosimon, (+)-isolariciresinol, cleomiscosin A, cleomiscosin C, cytotoxicity.

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References


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DOI: https://doi.org/10.15625/2525-2518/58/4/14877 Display counter: Abstract : 24 views. PDF : 5 views.

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