New quinazolinone derivatives: Synthesis and in vitro cytotoxic activity

Tran Dang Thinh; Le Thi Thuy; Ta Hong Duc; Tran Khac Vu

doi:10.15625/2525-2518/58/1/14391

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Authors

Tran Dang Thinh School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Le Thi Thuy School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Ta Hong Duc School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam
Tran Khac Vu School of Chemical Engineering, Hanoi University of Science and Technology No 1, Dai Co Viet, Hai Ba Trung, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/1/14391

Keywords:

6-Hydroxy-4(3H) quinazolinone, cytotoxic, cancer

Abstract

The paper presents a simple synthesis of new quinazolinone derivatives 13a-i. Synthesized derivatives were tested for their cytotoxic effect against three cancer cell lines including SKLU-1, MCF-7 and HepG-2. The bioassay result showed that only compound 13e exhibited significant cytotoxic effect against cancer cell lines tested with IC₅₀ values of 9.48, 20.39 and 18.04 µg/ mL, respectively.

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