CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

Polimati Haritha, Sunil Kumar Patnaik, Vinay Bharadwaj Tatipamula

Abstract


The chemical examination of ethanolic extract of manglicolous lichen Graphis ajarekarii (Ga-Et) resulted in isolation of three known metabolites – chiodectonic acid (1), graphenone (2) and graphisquinone (3). All the isolates (1-3) and Ga-Et were screened against DPPH and superoxide free radicals, six different cancer cell lines and one normal human cell line (NHME). This work is the first report of antioxidant and cytotoxicity studies on the isolated metabolites (1-3).

Keywords


manglicolous lichen, antioxidant, cancer, Sulforhodamine B assay

Full Text:

PDF

References


- Nayaka S., Ingle K. K., Bajpai R., Rawal J. R., Upreti D. K. and Trivedi S. – Lichens of Gujarat state, India with special reference to coastal habitats, Current Research in Environmental & Applied Mycology 3 (2) (2013)222-229.

- Tatipamula V. B., Vedula G. S. and Murthy K. S. – A note on the occurrence of lichens on Vainateya Godavari mangroves in East Godavari district of Andhra Pradesh India, Studies in Fungi 3 (1) (2018)302-308.

- Tatipamula V. B., Vedula G. S., Rathod B. B., Shetty P. R. and Sastry A. V. S – Study of phytochemical analysis, total flavonoid and phenolic content, antimicrobial properties and chemical constituents of two manglicolous lichens extracts, Inventi Rapid: Planta Activa 2018 (3) (2018)129-134.

- Kumar J., Dhar P., Tayade A. B., Gupta D., Chaurasia O. P., Upreti D. K., Arora R. and Srivastava R. B. – Antioxidant capacities, phenolic profile and cytotoxic effects of saxicolous lichens from Trans-Himalayan cold desert of Ladakh, PLoS One 9 (6) (2014)e98696.

- Logesh A. R., Kalaiselvam M., Upreti D. K., Nayaka S. and Karthiresan K. – Mangroves-an abode for unique lichens, Cocasal Ecosystems of India – Special Publication (2013)39-44.

- Behera B. C., Adawadkar B. and Makhija U. – Tissue-culture of selected species of the Graphis lichen and their biological activities, Fitoterapia 77 (3) (2006)208-215.

- Pittayakhajonwut P., Sri-Indrasutdhi V., Dramae A., Lapanun S., Suvannakad R. and Tantichareon M. Graphisins A and B from the lichen Graphis tetralocularis, Aust J Chem 62 (4) (2009)389-391.

- Talluri M. R., Ketha A., Battu G. R., Tadi R. S. and Tatipamula V. B. – Protective nature of Aurelia aurita against free radicals and Streptozotocin-induced diabetes, Bangladesh J Pharmacol 13 (3) (2018) 287-295.

- Tatipamula V. B., Vedula G. S., Paidi K. R. and Annam S. S. P. – Nutraceutical value of lichens, Graphis ajarekarii and Parmotrema tinctorum and their implications in diabetes, Inventi Impact: Nutraceuticals, 2018 (3) (2018)189-194.

- Tatipamula V. B., Vedula G. S. – In vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts, Hygeia J D Med 10 (1) (2018)16-26.

- Vichai V., Kirtikara K. – Sulforhodamine B colorimetric assay for cytotoxicity screening, Nat Protoc 1 (3) (2006)1112-1116.

- Sastry A. V. S., Vedula G. S. and Tatipamula V. B. – In-vitro biological profile of mangrove associated lichen, Roccella montagnei extracts, Inventi Impact: Ethnopharmacology 2018 (3) (2018)153-158.

- Tatipamula V. B., Kolli M. K., Lagu S. B., Paidi K. R., Reddy P. R. and Yejella R. P. – Novel indolizine derivatives lowers blood glucose levels in Streptozotocin-induced diabetic rats: A histopathological approach, Pharmacol Rep 71 (2) (2019)233-242.




DOI: https://doi.org/10.15625/2525-2518/57/3/13679 Display counter: Abstract : 114 views. PDF : 35 views.

Refbacks

  • There are currently no refbacks.


Index: Google Scholar; Crossref; VCGate; Asean Citation Index

Published by Vietnam Academy of Science and Technology