Effect of high glucose-induced hyperglycemia on Viral Haemorrhagic Septicaemia Sirus (VHSV) infection in adult zebrafish

Tran Van Cuong; Nguyen Thi Thoa

doi:10.15625/2525-2518/58/1/13530

Author affiliations

Authors

Tran Van Cuong Faculty of Agriculture and Forestry, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak, Viet Nam
Nguyen Thi Thoa The Western Highland Agriculture and Forestry Science Institute, 53 Nguyen Luong Bang, Buon Ma Thuot, Dak Lak, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/1/13530

Keywords:

Diabetes mellitus, glucose, hyperglycemia, VHSV, zebrafish

Abstract

This study, we conducted a high glucose immersion protocol to induce hyperglycemic zebrafish, later on, with the aim to evaluate the relationship between hyperglycemia and VHSV infection using the zebrafish model. As the results, zebrafish immersed in a 2000 ppm glucose solution for 10 days, FBG has increased two times as compared to control. In addition, hyperglycemic zebrafish was more susceptible to the virus infection resulted in increased the viral mRNA expression levels as well as the viral copy number as 1.7 Log higher than control.

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