INVESTIGATION IN LOADING 5-FLUOROURACIL ABILITY OF IRON-ORGANIC FRAMEWORKS

Nguyễn Thị Hoài Phương, Ninh Đức Hà

Abstract


Materials MIL-53(Fe), MIL-88(Fe) and MIL-100(Fe) have the ability to absorb many different compounds. In addition, the materials are small in size, highly bio-compatible, with no human toxicity. These materials were chosen to carry 5-fluorouracil (5-FU) for cancer treatment. Synthetic materials were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and surface characteristics (BET). 5-FU loading and releasing ability of MIL-53(Fe), MIL-88(Fe) and MIL-100(Fe) have been investigated by UV-Vis spectrophotometer. The results showed that the MIL-53(Fe), MIL-88(Fe), and MIL-100(Fe) are capable of carrying 5-FU with capacity exceeding 0.131 g/g, 0.28 g/g, 0.66 g/g respectively and mostly released after 10 days. The cancer cell toxicity and slow drug release ability of MIL(Fe)@5-FU were also tested by in-vitro method. Iron-organic frameworks are promising materials for cancer treatment.

Keywords


MIL-53 (Fe); MIL-88 (Fe); MIL-100 (Fe); drug delivery; 5-FU; cancer treatment

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References


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