Quang Ngoc Dang


Five fungal secondary metabolites named 1,2,4,5-tetrachloro-3,6-dimethoxybenzene (1); ergosterol (2); ergosterol peroxide (3); (E)- 4-(3,4-dihydroxyphenyl)but-3-en-2-one (4) and [Bi-1,4-cyclohexandien-1-yl]-3,3’,6,6’-tetrone, 4, 4’-dihydroxyl-2,2’,5,5’-tetramethyl (5) were purified from ethyl acetate extract of the fruit bodies of Phellinus gilvus collected at Pu Mat national park, Nghe An province. Their structures were charaterized by 1D, 2D NMR and GC-MS spectroscopies. Especially, the structure of compound 1 was confirmed by X-ray crystallographic analysis. The antimicrobial and cytotoxicity activities of compounds 1 were also evaluated. This is the first report on the chemical constituents of Vietnamese Phellinus gilvus.


Phellinus gilvus, metabolites, antimicrobial, cytotoxicity

Full Text:



Benjamin D. R. - Mushrooms poisons and panaceas, W. H. Freeman and Company, New York, USA (1995).

Bae J.S., Jang K.H., Yim H., Jin H.K. - Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice, Cancer. Lett. 218 (2005) 43–52.

Bae J.S., Jang K.H., Jin H.K. - Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats, J. Vet. Sci. 6 (2005) 161–164.

Chang Z.Q., Gebru E., Lee S.P., Rhee M.H., Kim J.C., Cheng H., Park S.C. - In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from Phellinus gilvus, J. Nutr. Sci. Vitaminol 57 (2011) 118122.

Ragasa C.Y., Tan M.C.S., De Castro M.E.G., Altena I.A. - Chemical constituents of Phellinus gilvus (Schwein.) Pat., Der Pharma Chemica 8 (2016) 222225.

Liu H.K., Tsai T. H., Chang T.T., Chou C.J., Lin L.C. - Lanostane-triterpenoids from the fungus Phellinus gilvus, Phytochemistry 70 (2009) 558563.

Lee I.K., Yun B.S. - Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus, Bioorg. Med. Chem. Lett. 15 (2007) 33093314.

Reich H.J., Jautelat M., Messe M.T., Weigert F.J., Roberts, J.D. - Nuclear magnetic resonance spectroscopy. Carbon 13 spectra of steroids. J. Am. Chem. Soc. 91 (1969) 7445–7454.

Mo S., Wang S., Zhou G., Yang Y., Li Y., Chen X., Shi J.- Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius. J. Nat. Prod. 67 (2004) 823828.

Tuan N.N., Thanh N.T., Dau N.T.H., Thang T.D. – Study on the chemical constituents of Vietnamese Phellinus pini. Vietnamese Journal of Chemistry 53 (6E12) (2015) 305308.

Thanh N.T., Tuan N.N., Huyen N.T., Thang T.D.-Chemical constituents from the fruiting bodies of Phellinus igrianius (Dc. ex Fr.) Quél. Vietnamese Journal of Science and Technology 54 (2B) (2016) 136-141.

Thanh N.T., Tuan N.N., Trung H.V., Thang T.D.- Phenolic and steroid compounds from Vietnamese Phellinus igrianius. Journal of Science, VNU: Natural Science and Technology 32 (2016) 264268.

Thanh N.T., Tuan N.N., Kuo P.C., Dung D.M., Phuong D.L, Thang T.D., Wu T.S. -Chemical constituents from the fruiting bodies of Phellinus igniarius, Natural Product Research, published online (2018).

Hien B.T.T.- Study on the chemical constituents and biological active compounds from some Vietnamese mushrooms. Doctoral thesis in Chemistry (2017).

Hadacek F., Greger H.-Testing of antifungal natural products: Methodologies, comparability of results and assay choice. Phytochem. Anal. 11 (2000) 137-147.

Scudiero D.A., Shoemaker R.H., Kenneth D.P., Monks A., Tierney S., Nofziger, T.H., Currens M.J., Seniff D., and Boyd M.R.-Evaluation of a soluable tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Can Res 48 (1988) 4827-4833.



  • There are currently no refbacks.

Index: Google Scholar; Crossref; VCGate; Asean Citation Index

Published by Vietnam Academy of Science and Technology