The triterpenoid and steroid from the fruiting body of Ganoderma applanatum (Pers.) Pat. In Viet Nam

Hoang Van Trung, Nguyen Tan Thanh, Nguyen Ngoc Tuan, Doan Manh Dung, Tran Dinh Thang
Author affiliations

Authors

  • Hoang Van Trung School of Chemistry, Biology and Environment, Vinh University, Vinh City, Viet Nam
  • Nguyen Tan Thanh School of Chemistry, Biology and Environment, Vinh University, Vinh City, Viet Nam
  • Nguyen Ngoc Tuan Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Doan Manh Dung Hue University of Science-Hue University, 77 Nguyen Hue, Hue City, Viet Nam
  • Tran Dinh Thang School of Chemistry, Biology and Environment, Vinh University, Vinh City, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/56/5/12588

Keywords:

Ganoderma applanatum, triterpenoid, steroid, lanosta-7, 9(11), 24-triene-3, 26-diol

Abstract

Five compounds, ergosterol (1), 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (2); ergosta-7,22-dien-3β-ol (3); lanosta-7,9(11),24-triene-3,26-diol (4) and 3β-hydroxy-5α-lanosta-7,9,24(E)-trien-26-oic acid (5) were isolated from fruiting body of Ganoderma applanatum (Pers.) Pat.  (Ganodermataceae). The structures of the isolated compounds were established by spectroscopic methods (UV, IR, MS, 1H-NMR, 13C-NMR, DEPT, COSY, HSQC and HMBC). These compounds were isolated from the Vietnamese fungi for the first time. Moreover, the lanosta-7,9(11),24-triene-3,26-diol is the first compound was found in the fungi.

Downloads

Download data is not yet available.

References

Isaka M., Chinthanom P., Kongthong S., Srichomthong K. and Choeklin R. - Lanostane triterpenes from cultures of the basidiomycete Ganoderma orbiforme BCC 22324. Phytochemistry 87 (2013) 133–139.

Yuen J. W. M. and Gohel M. D. I. - Anticancer effects of Ganoderma lucidum: A review of scientific evidence, Nutr. Cancer 53 (2005) 11–17.

El-Mekkawy S., Meselhy M. R., Nakamura N., Tezuka Y., Hattori M., Kakiuchi N., Shimotohno K., Kawahata T. and Otake T. - Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49 (1998) 1651–1657.

Liu G. Q. and Zhang, K. C. - Mechanisms of the anticancer action of Ganoderma lucidum (Leyss. Ex Fr.) Karst: A new understanding, J. Integr. Plant Biol. 47 (2005) 129–135.

Lin Z. B. and Zhang, H. N. - Antitumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms, Acta. Pharmacol. Sin. 25 (2004) 1387–1395.

Gao Y.H. and Zhou, S. F. - Chemopreventive and tumoricidal properties of lingzhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromy cetideae). Part II. Mechanism considerations (review), Int. J. Med. Mushrooms 6 (2004) 219–230.

Li P., Deng Y. P., Wei X. X. and Xu J. H. - Triterpenoids from Ganoderma lucidum and their cytotoxic activities. Nat. Prod. Res. 27 (2013) 17–22.

Kleinwächter P., Anh N., Kiet T. T., Schlegel B., Dahse H. M., Härtl A. And Gräfe U. - Colossolactones, new triterpenoid metabolites from a Vietnamese mushroom Ganoderma colossum. J. Nat. Prod. 64 (2001) 236–239.

Luo J. and Lin Z. B. - Advances of pharmacological effects of triterpenes from Ganoderma lucidum, Acta Pharmacol. Sin. 37 (2002) 574–578.

Boh B., Berovic M., Zhang J. and Lin Z. B. - Ganoderma lucidum and its pharmaceutically active compounds, Biotechnol. Annu. Rev. 13 (2007) 265–301.

Xie J. T., Wang C. Z., Wicks S., Yin J. J., Kong J., Li J., Li Y. C. and Yuan C. S. - Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum, Chem. Biodivers. 4 (2007) 224–231.

Xu Z., Chen X., Zhong Z., Chen L. and Wang Y. - Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities, Am. J. Chin. Med. 39 (2011) 15–27.

Yoshihisa T., Minoru U., Takashi O., Kimiko N., Koutarou M. and Toshiaki T. - Glycosides of ergosterol derivatives from Hericum erinacens, Phytochemistry 30 (12) (1991) 4117-4120.

Liu J. and William D. N. - Steroidal triterpens: Design of substrate-based inhibitors of ergosterol and sitosterol synthesis, Molecules 14 (2009) 4690-4706.

Kim D. S., Baek N. I., Oh S. R., Jung K. Y., Lee I. S., Kim J. H. and Lee H. K. - Anticomplementary activity of ergosterol peroxide from Naematoloma fasciculare and reassignment of NMR data, Arch. Pharm. Res. 20 (3) (1997) 201-205.

Keller A. C., Maillard M. P. and Hostettmann K. - Antimicrobial steroids from the fungus Fomitopsis pinicola, Phytochemistry 41 (1996) 1041-1046.

Takaishi Y., Ohashi T. and Tomimatsu T. - Ergosta-7,22-dien-3β-ol glycoside from Tylopilus neofelleus, Phytochemistry 28 (3) (1989) 945-947.

Toth J. O., Luu B., Beck J. P. and Ourisson G. - Triterpenes cytotoxiques de Ganoderma lucidum (Polyporaceae): Structures of ganoderic acids U-Z.. J. Chem. Res. (S) 299 (M) (1983) 2722-2787.

Downloads

Published

10-10-2018

How to Cite

[1]
Hoang Van Trung, Nguyen Tan Thanh, Nguyen Ngoc Tuan, Doan Manh Dung, and Tran Dinh Thang, “The triterpenoid and steroid from the fruiting body of Ganoderma applanatum (Pers.) Pat. In Viet Nam”, Vietnam J. Sci. Technol., vol. 56, no. 5, pp. 550–556, Oct. 2018.

Issue

Section

Natural Products

Most read articles by the same author(s)