Acute and subacute toxic study on mice of glipizide synthesized in Viet Nam

Thi Thoi Bui; Dai Quang Ngo; Van Loc Tran; Van Chien Tran; Thi Nga Nguyen; Thi Thao Do

doi:10.15625/2525-2518/57/1/12274

Acute and subacute toxic study on mice of glipizide synthesized in Viet Nam

Thi Thoi Bui, Dai Quang Ngo, Van Loc Tran, Van Chien Tran, Thi Nga Nguyen, Thi Thao Do

Author affiliations

Authors

Thi Thoi Bui Vietnam Institute of Industrial Chemistry, 22 Pham Ngu Lao, Hoan Kiem, Ha Noi, Viet Nam
Dai Quang Ngo Viet Nam Nationnal Chemical Group, 1A Trang Tien, Hoan Kiem, Ha Noi, Viet Nam
Van Loc Tran Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Van Chien Tran Institute of Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Thi Nga Nguyen Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Thi Thao Do Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/57/1/12274

Abstract

Glipizide is a second generation of sulfonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. Glipizide is absorbed rapidly, uniformly with good mean oral bioavailability. It offers several advantages such as swift and short action, high potency and also does not accumulate in plasma on repeated oral administration. In this paper we report the acute and subacute toxicity of glipizide on BALB/c albino mice. The results showed the safety of our synthesized products.

Downloads

Download data is not yet available.

Downloads

Published

18-02-2019

How to Cite

[1]

T. T. Bui, D. Q. Ngo, V. L. Tran, V. C. Tran, T. N. Nguyen, and T. T. Do, “Acute and subacute toxic study on mice of glipizide synthesized in Viet Nam”, Vietnam J. Sci. Technol., vol. 57, no. 1, pp. 15–21, Feb. 2019.

IEEE

Download Citation

Issue

Vol. 57 No. 1 (2019)

Section

Natural Products

License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Vietnam Journal of Sciences and Technology (VJST) is an open access and peer-reviewed journal. All academic publications could be made free to read and downloaded for everyone. In addition, articles are published under term of the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA) Licence which permits use, distribution and reproduction in any medium, provided the original work is properly cited & ShareAlike terms followed.

Copyright on any research article published in VJST is retained by the respective author(s), without restrictions. Authors grant VAST Journals System a license to publish the article and identify itself as the original publisher. Upon author(s) by giving permission to VJST either via VJST journal portal or other channel to publish their research work in VJST agrees to all the terms and conditions of https://creativecommons.org/licenses/by-sa/4.0/ License and terms & condition set by VJST.

Authors have the responsibility of to secure all necessary copyright permissions for the use of 3rd-party materials in their manuscript.