INVESTIGATING THE ANTI-INFLAMMATORY ACTIVITY OF AN ETHANOLIC EXTRACT FROM ARTOCARPUS TONKINENSIS LEAVES USING A COLLAGEN ANTIBODY-INDUCED ARTHRITIC MOUSE MODEL

Trinh Thi Thuy, Tran Duc Quan, Nguyen Thanh Tam, Nguyen Thi Hoang Anh, Nguyen Thi Cuc, Nguyen Thi Nga, Tran Van Sung, Le Thi Hong Nhung, Nguyen Hoang Sa, Sabrina Adorisio, Domenico V. Delfino, Do Thi Thao

Abstract


The obtained results here demonstrate that the 70% ethanolic leaf extract of A. tonkinensis (AT2), traditionally used in Vietnamese folk medicine for treating arthritic symtoms, has beneficial effects on pro-inflammatory cytokine inhibition and in an experimental arthritic mouse model. LPS-stimulated RAW 264.7 macrophages treated with AT2 showed a significant decrease in the production of IL-6 and TNFa at concentrations of 12.5, 25 and 50 µg/mL (P<0.05), indicating its potential anti-inflammatory properties. Treatment of CAIA mice with AT2 also led to diminish the incidence of arthritis at doses of 200 and 300 mg/kg body weight.


Keywords


Artocarpus tonkinensis, autoimmune, interleukin 6, inflammation, rheumatoid arthritis, TNF-alpha

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DOI: https://doi.org/10.15625/2525-2518/56/3/11105

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Published by Vietnam Academy of Science and Technology