Facile Synthesis of CuO/ITO Film Via the Chronoamperometric Electrodeposition for Nonenzymatic Glucose Sensing

Duong Thi Thuy Tran, Dung Quoc Nguyen, Chuyen Hong Pham, Lam Dai Tran, Dai Tien Nguyen


We report on the synthesis of copper (II) oxide (CuO)/indium tin oxide (ITO) electrode via the electrochemical deposition method using a CuSO4 solution and then thermal oxidation in air at temperature of 400 oC for 2 h. The crystalline structure and morphology of CuO were characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). The electrochemical properties of the CuO/ITO electrode to glucose in the alkaline medium of 0.1 M NaOH solution were investigated by cyclic voltammetry (CV) and Chronnoamperometry. The CuO-N/ITO electrode showed the best electrochemical properties for glucose detection in comparison to the others. Chronnoamperometry of CuO-N/ITO electrode to the glucose response showed excellent stability, the linear range of 1 mM to 3600 mM with high sensitivity of 283.6 mAcm-2mM-1 and 0.61 mM of the detection limit (S/N=3). A good response of the CuO-N/ITO electrode, which was investigated for different human serum samples, indicates a high potential of its towards a glucose sensor for analysis in real examples.


copper (II) oxide, glucose sensing, chronoamperometry, cyclic voltammetry, human serum

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N.Q. Dung, D. Patil, T.T. Duong, H. Jung, D. Kim, S.G. Yoon, An amperometric glucose biosensor based on a GOx-entrapped TiO2-SWCNT composite, Sensors Actuators, B Chem. 166–167 (2012) 103–109. doi:10.1016/j.snb.2012.01.008.

N. Quoc Dung, D. Patil, H. Jung, D. Kim, A high-performance nonenzymatic glucose sensor made of CuO-SWCNT nanocomposites, Biosens. Bioelectron. 42 (2013) 280–286. doi:10.1016/j.bios.2012.10.044.

N.Q. Dung, D. Patil, H. Jung, J. Kim, D. Kim, NiO-decorated single-walled carbon nanotubes for high-performance nonenzymatic glucose sensing, Sensors Actuators, B Chem. 183 (2013) 381–387. doi:10.1016/j.snb.2013.04.018.

N.Q. Dung, T.T.T. Duong, T.D. Lam, D.D. Dung, N.N. Huy, D. Van Thanh, A simple route for electrochemical glucose sensing using background current subtraction of cyclic voltammetry technique, J. Electroanal. Chem. (2019) 113323. doi:https://doi.org/10.1016/j.jelechem.2019.113323.

L.C. Clark, C. Lyons, Electrode Systems for Continuous Monitoring in Cardiovascular Surgery, Ann. N. Y. Acad. Sci. 102 (1962) 29–45. doi:10.1111/j.1749-6632.1962.tb13623.x.

M. Viticoli, A. Curulli, A. Cusma, S. Kaciulis, S. Nunziante, L. Pandolfi, F. Valentini, G. Padeletti, Third-generation biosensors based on TiO2 nanostructured films, Mater. Sci. Eng. C. 26 (2006) 947–951.

K.M. El Khatib, R.M.A. Hameed, Development of Cu2O/Carbon Vulcan XC-72 as non-enzymatic sensor for glucose determination, Biosens. Bioelectron. 26 (2011) 3542–3548.

Y. Wei, Y. Li, X. Liu, Y. Xian, G. Shi, L. Jin, ZnO nanorods/Au hybrid nanocomposites for glucose biosensor, Biosens. Bioelectron. 26 (2010) 275–278.

B. Yuan, C. Wang, L. Li, S. Chen, Real time observation of the anodic dissolution of copper in NaCl solution with the digital holography, Electrochem. Commun. 11 (2009) 1373–1376.

L.-C. Jiang, W.-D. Zhang, A highly sensitive nonenzymatic glucose sensor based on CuO nanoparticles-modified carbon nanotube electrode, Biosens. Bioelectron. 25 (2010) 1402–1407.

X. Xiao, H. Li, Y. Pan, P. Si, Non-enzymatic glucose sensors based on controllable nanoporous gold/copper oxide nanohybrids, Talanta. 125 (2014) 366–371.

S. Yang, G. Li, D. Wang, Z. Qiao, L. Qu, Synthesis of nanoneedle-like copper oxide on N-doped reduced graphene oxide: a three-dimensional hybrid for nonenzymatic glucose sensor, Sensors Actuators B Chem. 238 (2017) 588–595.

D. Jiang, Q. Liu, K. Wang, J. Qian, X. Dong, Z. Yang, X. Du, B. Qiu, Enhanced non-enzymatic glucose sensing based on copper nanoparticles decorated nitrogen-doped graphene, Biosens. Bioelectron. 54 (2014) 273–278.

M. Saraf, K. Natarajan, S.M. Mobin, Non-enzymatic amperometric sensing of glucose by employing sucrose templated microspheres of copper oxide (CuO), Dalt. Trans. 45 (2016) 5833–5840.

C.-Y. Chiang, K. Aroh, N. Franson, V.R. Satsangi, S. Dass, S. Ehrman, Copper oxide nanoparticle made by flame spray pyrolysis for photoelectrochemical water splitting–Part II. Photoelectrochemical study, Int. J. Hydrogen Energy. 36 (2011) 15519–15526.

C.-Y. Chiang, Y. Shin, K. Aroh, S. Ehrman, Copper oxide photocathodes prepared by a solution based process, Int. J. Hydrogen Energy. 37 (2012) 8232–8239.

S.M. Cha, G. Nagaraju, S.C. Sekhar, J.S. Yu, A facile drop-casting approach to nanostructured copper oxide-painted conductive woven textile as binder-free electrode for improved energy storage performance in redox-additive electrolyte, J. Mater. Chem. A. 5 (2017) 2224–2234.

C.R. Crick, I.P. Parkin, CVD of copper and copper oxide thin films via the in situ reduction of copper (ii) nitrate-a route to conformal superhydrophobic coatings, J. Mater. Chem. 21 (2011) 14712–14716.

Z.-Y. Tian, H.J. Herrenbrück, P.M. Kouotou, H. Vieker, A. Beyer, A. Gölzhäuser, K. Kohse-Höinghaus, Facile synthesis of catalytically active copper oxide from pulsed-spray evaporation CVD, Surf. Coatings Technol. 230 (2013) 33–38.

A. Kowalik-Klimczak, E. Stanisławek, J. Kacprzyńska-Gołacka, B. Kaźmierczak, P. Wieciński, The polyamide membranes modified by copper oxide using PVD techniques, J. Mach. Constr. Maintenance. Probl. Eksploat. (2018).

DOI: https://doi.org/10.15625/0868-3166/30/2/14801 Display counter: Abstract : 140 views. PDF : 63 views.


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